Sarah Guo

1/The small but mighty @chaidiscovery team has released Chai-1, an open-weights, frontier multimodal molecular structure prediction model, on par with AlphaFold3. As powerful as Chai-1 is, it was shipped after only 4 months of work — and is just a glimpse of what’s coming. 2/ More than just a technical milestone, Chai is a signal of the coming structural shift for pharma. Molecular structure and interaction prediction at scale will reduce the time and cost of drug discovery, shifting risk “left” into silico and away from expensive labs and trials. 3/ Lower barrier to entry enables scientists to innovate faster and more successfully. The shi…

this energy

What is the best example, in the history of technology, of defensible software IP? Not a large system (like crawl/rank/serving), distribution, ecosystem, capex/manufacturing like a semi fab, supply chain capability, UGC, etc. Just straight IP. E.g., code/algo…bundle of weights?

🆕 One of my favorite @NoPriorsPod discussions: the wonderful @karpathy on - status of autonomy, tesla v. waymo - humanoid robots - bottlenecks to AGI - our future exo-brains - small models, open source - eureka labs, education - what young people should study in the age of AI https://t.co/1dNf9CT0Qj Full interview links: Youtube https://t.co/ZIpmOcJZ4A Spotify https://t.co/Tt78DGNcml Apple https://t.co/eiQj8W0KQp

.@elonmusk can you please improve X long video upload speed? it's major deterrent to making content native to platform

I cannot wait to buy greater intelligence

We need to have a realistic, rather than romanticized understanding of manufacturing that is globally competitive https://t.co/9eHHxx8SMd

https://t.co/yBKiHlmq8l